Scientific Advisory Board¶
The Scientific Advisory Board (SAB)ย was formed to review the PANORAMA study design and outcome.ย Members of the SAB were asked to collaborate on the following aspects of the study:¶
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Definition of study outcome: In collaboration with the SAB the intended predicted outcome, which is crucial to address the pressing clinical problem of detecting (early-staged) PDAC on routine CECT scans, was defined to match clinical expectations and drive AI development.
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Definition of reference standard: The PANORAMA study aims to provide the best possible evidence forย the presence and location (or absence) of PDAC on abdominal CECT while maintaining a representative patient distribution in the testing cohort. For each patient exam in this cohort, CECT studies, clinical variables (e.g., sex, age), diagnostic radiology reports, biopsy/resection histopathology reports, and follow-up information (if available) will be used to manually annotate all pancreatic lesions.ย
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AI validation: All evaluation/analyses will be made using task-specific metrics in compliance with expert recommendations for grand challenges, with the goal of facilitating meaningful validation of AI towards clinical translation (Reinke et al., 2021).ย ย
Artificial Intellingence¶
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Statistics¶
