Theย Scientific Advisory Board (SAB)ย was formed to review the PANORAMA study design and outcome.ย Members of the SAB were asked to collaborate on the following aspects of the study:
Definition of study outcome: In collaboration with the SAB the intended predicted outcome, which is crucial to address the pressing clinical problem of detecting (early-staged) PDAC on routine CECT scans, was defined to match clinical expectations and drive AI development.
Definition of reference standard: The PANORAMA study aims to provide the best possible evidence forย the presence and location (or absence) of PDAC on abdominal CECT while maintaining a representative patient distributionin the testing cohort. For each patient exam in this cohort, CECT studies, clinical variables (e.g.,sex, age), diagnostic radiology reports, biopsy/resection histopathology reports, and follow-up information (if available) will be used to manually annotate all pancreatic lesions.ย
AI validation:ย All evaluation/analyses will be made using task-specific metrics in compliance with expert recommendations for grand challenges, with the goal offacilitating meaningful validation of AI towards clinical translation (Reinke et al., 2021).ย ย
